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Together, these results mean that the metabolites of gut microbiota disturb regulation of joint FTN and homeostasis of iron, thereby may inducing iron overload that triggers ferroptosis and accelerate the development of OA

The closest analog (cagrilintide + semaglutide) has Phase 3 data showing meaningful additive benefit over semaglutide alone

76 Other recent analyses have revealed survodutide, tirzepatide, and retatrutide to each significantly reduce liver fat with no evidence of worsening in markers of liver fibrosis.77, 78, 79 Depression and suicidality Most studies evaluating depression and GLP-1 RA use were conducted in those with T2DM and indicate no increased risk